Conserved Site

ATPase, OSCP/delta subunit, conserved site (IPR020781)

Short name: ATPase_OSCP/d_CS


ATP synthase (proton-translocating ATPase) [PMID: 2528322, PMID: 2892214] is a component of the cytoplasmic membrane of eubacteria, the inner membrane of mitochondria, and the thylakoid membrane of chloroplasts. The ATPase complex is composed of an oligomeric transmembrane sector, called CF(0), which acts as a proton channel, and a catalytic core, termed coupling factor CF(1).

One of the subunits of the ATPase complex, known as subunit delta in bacteria and chloroplasts, or the Oligomycin Sensitivity Conferral Protein (OSCP) in mitochondria, seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is involved in proton conduction [PMID: 2154253].

The different delta/OSCP subunits are proteins of approximately 200 amino-acid residues - once the transit peptide has been removed in the chloroplast and mitochondrial forms - which show only moderate sequence homology.

This entry represents a conserved site in the C-terminal section of these proteins.

GO terms

Biological Process

GO:0015986 ATP synthesis coupled proton transport

Molecular Function

GO:0046933 proton-transporting ATP synthase activity, rotational mechanism

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns