Ephrin type-A receptor 8 (IPR020691)
Short name: EphrinA_rcpt8
Overlapping homologous superfamilies
- Ephrin receptor type-A /type-B (IPR016257)
- Ephrin type-A receptor 8 (IPR020691)
Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups [PMID: 12471243]:
- Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis [PMID: 19275641]. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction [PMID: 16700535].
- Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [PMID: 15845350].
This entry represents ephrin type-A receptor 8, which is a receptor tyrosine kinase that binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighbouring cells [PMID: 12094214].
- PTHR24416:SF339 (PTHR24416:SF339)