Family

Ephrin type-A receptor 8 (IPR020691)

Short name: EphrinA_rcpt8

Family relationships

Description

Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups [PMID: 12471243]:

  • Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis [PMID: 19275641]. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction [PMID: 16700535].

  • Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [PMID: 15845350].

This entry represents ephrin type-A receptor 8, which is a receptor tyrosine kinase that binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighbouring cells [PMID: 12094214].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005004 GPI-linked ephrin receptor activity
GO:0004713 protein tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER