Rho-associated protein kinase 1/2 (IPR020684)

Short name: ROCK1/ROCK2

Overlapping homologous superfamilies


Family relationships


Eukaryotic protein kinases [PMID: 7768349, PMID: 1835513, PMID: 1956325, PMID: 3291115] are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases.

Rho kinases are serine/threonine kinases that are important in cell migration, cell proliferation and cell survival. Disorders of the central nervous system including stroke, inflammatory and demyelinating diseases, Alzheimer's disease and neuropathic pain may be linked to abnormal activation of Rho kinases [PMID: 15864268].

This entry represents a set of Rho-associated, coiled-coil-containing, protein kinases. They phosphorylate a large number of important signalling proteins and help regulate the assembly of the actin cytoskeleton. Proteins in this entry have been shown to play a role in smooth muscle formation, and promote the formation of stress fibres and of focal adhesion complexes [PMID: 8772201, PMID: 12832488].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.