Adenylate kinase isoenzyme 6 (IPR020618)

Short name: Adenyl_kinase_AK6

Overlapping homologous superfamilies

Family relationships



Adenylate kinase isoenzyme 6 (AK6) is a broad-specificity nucleoside monophosphate (NMP) kinase that catalyses the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates [PMID: 15630091]. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. It has also ATPase activity and may have a role in nuclear energy homeostasis. AK6 is involved in regulation of Cajal body (CB) formation [PMID: 16079131, PMID: 22038794].

This entry also includes related putative adenylate kinases from archaea.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0004017 adenylate kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.