Conserved Site

MnmG-related, conserved site (IPR020595)

Short name: MnmG-rel_CS

Description

MnmG (also known as GidA) is a tRNA modification enzyme found in bacteria and mitochondria. Though its precise molecular function of these proteins is not known, it is involved in the 5-carboxymethylaminomethyl modification of the wobble uridine base in some tRNAs [PMID: 15509579, PMID: 11544186]. Sequence variations in the human mitochondrial protein may influence the severity of aminoglycoside-induced deafness [PMID: 15542390].

This entry includes MnmG and related proteins, such as the methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase enzyme TrmFO.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns