Conserved Site

Gamma-glutamyl phosphate reductase GPR, conserved site (IPR020593)

Short name: G-glutamylP_reductase_CS


Gamma-glutamyl phosphate reductase (EC: (GPR) is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate, the NADP-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. In bacteria (gene proA) and yeast [PMID: 8896266] (gene PRO2), GPR is a monofunctional protein, while in plants and mammals, it is a bifunctional enzyme (P5CS) [PMID: 1384052] that consists of two domains, an N-terminal glutamate 5-kinase domain (EC: and a C-terminal GPR domain.

This signature pattern covers a conserved region that contains two histidine residues. This region is located in the last third of GPR.

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006561 proline biosynthetic process

Molecular Function

GO:0004350 glutamate-5-semialdehyde dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns