Glycine cleavage system P-protein, N-terminal (IPR020580)

Short name: GDC-P_N

Domain relationships


This family consists of glycine cleavage system P-proteins (EC: from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex (EC: (GDC) also annotated as glycine cleavage system or glycine synthase. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor, carbon dioxide is released and the remaining methylamin moiety is then transferred to the lipoamide cofactor of the H protein. GDC consists of four proteins P, H, L and T [PMID: 8181752]. The reaction catalysed by this protein is:

Glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2

GO terms

Biological Process

GO:0006546 glycine catabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004375 glycine dehydrogenase (decarboxylating) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.