Conserved Site

Uncharacterised protein family UPF0029, Impact, conserved site (IPR020569)

Short name: UPF0029_Impact_CS

Description

This entry contains the protein Impact, which is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea [PMID: 11116084].

This signature pattern matches a conserved region.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns