Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain (IPR020561)

Short name: PRibGlycinamid_synth_ATP-grasp

Domain relationships

  • ATP-grasp fold (IPR011761)
    • Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain (IPR020561)


Phosphoribosylglycinamide synthetase (EC: (GARS) (phosphoribosylamine glycine ligase) [PMID: 2687276] catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide: ATP + 5-phosphoribosylamine + glycine = ADP + Pi + 5'-phosphoribosylglycinamide In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5/7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (IPR000728). In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS (IPR000728) and with phosphoribosylglycinamide formyltransferase (GART) (IPR001555 ), forming GARS-AIRS-GART.

This entry represents the A-domain of the enzyme, and is related to the ATP-grasp domain of biotin carboxylase/carbamoyl phosphate synthetase.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.