Interleukin-15, mammal (IPR020466)

Short name: IL-15_mml

Overlapping homologous superfamilies


Family relationships


Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cellular immune responses [PMID: 10689297]. It is required for division of CD8+ T cells of memory phenotype - a process that is increased by inhibition of IL-2 [PMID: 10784451]. The numbers of CD8+ memory T cells in animals may, therefore, be controlled by a balance between IL-15 and -2.

IL-15 has been identified in mammals, birds and fish. This entry represents Mammalian IL-15s, that are expressed in a number of different tissues and cell types. Within the immune system, they are mainly produced by monocytes and macrophages [PMID: 8543827].

This entry represents interleukin-15 found in mammals.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.