Family

LanC-like protein, eukaryotic (IPR020464)

Short name: LanC-like_prot_euk

Family relationships

Description

The LanC-like protein superfamily encompasses a highly divergent group of peptide-modifying enzymes, including the eukaryotic and bacterial lanthionine synthetase C-like proteins (LanC) [PMID: 11474189, PMID: 10944443, PMID: 12566319]; subtilin biosynthesis protein SpaC from Bacillus subtilis [PMID: 1735728, PMID: 1539969]; epidermin biosynthesis protein EpiC from Staphylococcus epidermidis [PMID: 1740156]; nisin biosynthesis protein NisC from Lactococcus lactis [PMID: 8161176, PMID: 7689965, PMID: 1482192]; GCR2 from Arabidopsis thaliana (Mouse-ear cress) [PMID: 17347412]; and many others.

The 3D structure of the lantibiotic cyclase from L. lactis has been determined by X-ray crystallography to 2.5A resolution [PMID: 16527981]. The globular structure is characterised by an all-alpha fold, in which an outer ring of helices envelops an inner toroid composed of 7 shorter, hydrophobic helices. This 7-fold hydrophobic periodicity has led several authors to claim various members of the family, including eukaryotic LanC-1 and GCR2, to be novel G protein-coupled receptors [PMID: 17347412, PMID: 9512664]; some of these claims have since been corrected [PMID: 10944443, PMID: 18086512, PMID: 17894782].

The eukaryotic lanthionine synthetase C-like proteins 1-3, are relatives of the bacterial lanthionine synthetase components C (LanC) [PMID: 11474189, PMID: 10944443, PMID: 12566319]. They are ubiquitous in nature, being variously expressed in brain, spinal chord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis. LanC-like protein 2 is a bystander gene co-amplified and over- expressed with epidermal growth factor receptor (EGFR) in 20% of glioblastomas; its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) and increases cellular sensitivity to the anticancer drug adriamycin [PMID: 12566319].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS