Family

Acylphosphatase (IPR020456)

Short name: Acylphosphatase

Family relationships

Description

Acylphosphatase (EC:3.6.1.7) is an enzyme of approximately 98 amino acid residues that specifically catalyses the hydrolysis of the carboxyl-phosphate bond of acylphosphates [PMID: 1664426], its substrates including 1,3-diphosphoglycerate and carbamyl phosphate [PMID: 2538623]. The enzyme has a mainly beta-sheet structure with 2 short alpha-helical segments. It is distributed in a tissue-specific manner in a wide variety of species, although its physiological role is as yet unknown [PMID: 2538623]: it may, however, play a part in the regulation of the glycolytic pathway and pyrimidine biosynthesis [PMID: 2830253]. There are two known isozymes. One seems to be specific to muscular tissues, the other, called 'organ-common type', is found in many different tissues. A number of bacterial and archebacterial hypothetical proteins are highly similar to that enzyme and that probably possess the same activity.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003998 acylphosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS