Interleukin-16 (IPR020450)

Short name: IL-16

Overlapping homologous superfamilies


Family relationships



Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Interleukin-16 (IL-16, also known as lymphocyte chemoattractant factor) is a proinflammatory cytokine that signals via CD4, inducing chemotactic and immunomodulatory responses of CD4+ lymphocytes, monocytes and eosinophils [PMID: 7910967]. The cytokine has been implicated in the exacerbation of a number of infectious, immune-mediated and autoimmune inflammatory disorders, including atopic dermatitis, irritable bowel syndrome, systemic lupus erythematosus, neurodegenerative disorders, and viral infections [PMID: 16881862].

This entry represents interleukin-16.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005125 cytokine activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.