Tumour necrosis factor receptor 4 (IPR020445)

Short name: TNFR_4

Overlapping homologous superfamilies


Family relationships



The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type I transmembrane proteins. Family members are defined based on similarity in their extracellular domain, a region that contains many cysteine residues arranged in a specific repetitive pattern [PMID: 7917108]. The cysteines allow formation of an extended rodlike structure, responsible for ligand binding [PMID: 8387891].

Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [PMID: 15500863]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [PMID: 11239407, PMID: 9826575].

TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis [PMID: 15500863]. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease [PMID: 9826574].

This entry represents TNF receptor 4 (also known as OX40 and CD134 antigen) is expressed primarily on activated CD4(+) T cells. Activation of the receptor increases the proinflammatory activity of these cells and enhances their long-term survival [PMID: 9122217].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.