Family

Moubatin (IPR020398)

Short name: Moubatin

Family relationships

None.

Description

This entry represents moubatin, a salivary lipocalin found in soft ticks, such Ornithodoros moubata and Ornithodoros parkeri. Moubatin acts as a specific inhibitor of collagen-induced platelet aggregation. At higher concentrations it may affect more than one aspect of platelet signal transduction including the thromboxane A2 receptor.

Phylogenetic analysis showed that most tick lipocalins group within genus-specific clades, suggesting that gene duplication and divergence of tick lipocalin function occurred after tick speciation, most probably during the evolution of a hematophagous lifestyle [PMID: 12777525]. The moubatin-clade of soft tick lipocalins is most likely derived from the related histamine and serotonin-binding lipocalin sub-family that is conserved within the Argasidae. The ancestral function evolved in this clade was aimed at inhibition of vasoconstriction, platelet aggregation and neutrophil aggregation, primarily by scavenging of thromboxane A2 and leukotriene B4 [PMID: 18694828].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom