Homoserine lactone synthase LuxM/VanM, N-terminal (IPR020374)

Short name: LuxM/VanM_N

Overlapping homologous superfamilies


Domain relationships



This entry represents the N-terminal domain of homoserine lactone synthase protein LuxM and its homologue VanM.

This entry represents the homoserine lactone synthase protein LuxM and its homologue VanM. LuxM/VanM is required for the synthesis of various homoserine lactones. LuxM synthesises N-(3-hydroxybutanoyl)homoserine lactone, while VanM synthesises N-hexanoylhomoserine lactone (C6-HSL) and N-(3-hydroxyhexanoyl)homoserine lactone (3-hydroxy-C6-HSL). These AHLs act as autoinducer molecules, which bind to LuxN/VanN that encode a hybrid sensor kinase. Together, LuxM/LuxN (and VanM/VanN) form part of a phosphorelay cascade involved in the regulation of bioluminescence of Vibrio species [PMID: 16487746].

Note that although the luxL and luxM genes were previously thought to produce two independent gene products, resequencing of the Vibrio harveyi luxL/luxM junction revealed a sequencing error present in the published sequence, which when corrected resulted in a single open reading frame (termed luxM) [PMID: 11371516].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • PD097636 (hSer_lactone_synthase_LuxM_N)