Host transcription inhibitor Alc (IPR020367)

Short name: Host_transcript_inhib_Alc

Overlapping homologous superfamilies


Family relationships



Bacteriophage T4 infection rapidly shuts down transcription in the host cell and any other phages that may be present. This is accomplished by specifically blocking transcription of cytosine-containing DNA. T4 is protected from this as its DNA contains a substituted base, hydroxymethylcytosine, in place of the usual cytosine. The Alc protein plays a key role in this process by unfolding the host genome and blocking transcription of cytosine-containing DNA [PMID: 6389256, PMID: 3782028].

GO terms

Biological Process

GO:0039653 suppression by virus of host transcription

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.