Family

Host transcription inhibitor Alc (IPR020367)

Short name: Host_transcript_inhib_Alc

Family relationships

None.

Description

Bacteriophage T4 infection rapidly shuts down transcription in the host cell and any other phages that may be present. This is accomplished by specifically blocking transcription of cytosine-containing DNA. T4 is protected from this as its DNA contains a substituted base, hydroxymethylcytosine, in place of the usual cytosine. The Alc protein plays a key role in this process by unfolding the host genome and blocking transcription of cytosine-containing DNA [PMID: 6389256, PMID: 3782028].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom