Transcription regulator CaiF/GrlA (IPR020357)

Short name: Tscrpt_reg_CaiF/GrlA

Overlapping homologous superfamilies

Family relationships



This is a family of transcriptional regulators that includes CaiF and GrlA. CaiF is a specific carnitine-sensitive transcription regulator [PMID: 8631699]. CaiF and CRP, a cyclic AMP receptor protein, are required to activate the cai and fix operons, which are involved in anaerobic carnitine metabolism [PMID: 10564497]. GrlA is encoded within the LEE type III secretion system in the enteropathogenic E. coli O157:H [PMID: 24092262]. GrlR interacts with GrlA at its Helix-Turn-Helix (HTH) motif, preventing GrlA from binding to its target promoter DNA.

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • PD081346 (Transcription_activatory_CaiF)