Family

Heparin-binding haemagglutinin, bacteria (IPR020340)

Short name: Haemagglutinin_heparin-bd_bac

Family relationships

None.

Description

Heparin-binding haemagglutinin (HBHA) is required for extrapulmonary dissemination. It mediates adherence to epithelial cells by binding to sulphated glycoconjugates present at the surface of these cells. It binds heparin, dextran sulphate, fucoidan and chondroitin sulphate; and promotes hemagglutination of erythrocytes of certain host species [PMID: 11449276]. Heparin-binding hemagglutinin (HBHA) of Mycobacterium leprae is expressed during infection and enhances bacterial adherence to epithelial cells [PMID: 19220476]. Methylated HBHA has the potential to be an important component in future, acellular vaccines against tuberculosis [PMID: 16510310].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0009405 pathogenesis

Molecular Function

GO:0008201 heparin binding

Cellular Component

GO:0009986 cell surface

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
  • PD082580 (Heparin-binding_haemagglutinin)