Procorazonin (IPR020190)

Short name: Procorazonin

Overlapping homologous superfamilies


Family relationships



In Drosophila melanogaster (Fruit fly) the preprocorazonin consists of an 19 amino acid signal peptide, the 11 amino acid corazonin sequence followed by a 39 amino acid corazonin-precursor-related peptide (CPRP) and finally the 85 amino acid propeptide, Q26377 [PMID: 7945373].

Corazonin is a cardioactive peptide of insects, which is probably involved in the physiological regulation of the heart beat. Drosophila clock (clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner [PMID: 15669053]. Corazonin is expressed in neurosecretory neurons of the pars lateralis of the protocerebrum and transported via nervi corporis cardiaci to the storage lobes of the corpora cardiaca. The peptide occurs with a single isoform in all insects studied so far, with the exception of the Coleoptera in which none could be detected [PMID: 17140699].

GO terms

Biological Process

GO:0045823 positive regulation of heart contraction

Molecular Function

GO:0071858 corazonin receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.