Family

Antigen surface cell precursor, Sca1 (IPR020179)

Short name: Ag_surface_cell_prcur_Sca1

Family relationships

None.

Description

Sca1 is a autotransporter protein [PMID: 11557893], which is responsible for its own secretion across the outer membrane of Gram-negative bacteria. The carboxy-terminal beta-domain is thought to form a beta-barrel outer membrane porin that allows the amino-terminal passenger domain to pass through it in an unfolded state. The secreted passenger domain is then released from the transporter as a functional mature protein [PMID: 9778731].

This entry represents a putative surface cell antigen, SCA1 which is also called Ly6A/E or Ly6D [PMID: 955809]. The antigen surface cell antigen is expressed in immature hematopoietic progenitor cells and is confined to Rickettsia.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom