Antigen surface cell precursor, Sca1 (IPR020179)

Short name: Ag_surface_cell_prcur_Sca1

Overlapping homologous superfamilies


Family relationships



Sca1 is a autotransporter protein [PMID: 11557893], which is responsible for its own secretion across the outer membrane of Gram-negative bacteria. The carboxy-terminal beta-domain is thought to form a beta-barrel outer membrane porin that allows the amino-terminal passenger domain to pass through it in an unfolded state. The secreted passenger domain is then released from the transporter as a functional mature protein [PMID: 9778731].

This entry represents a putative surface cell antigen, SCA1 which is also called Ly6A/E or Ly6D [PMID: 955809]. The antigen surface cell antigen is expressed in immature hematopoietic progenitor cells and is confined to Rickettsia.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.