Herpesvirus glycoprotein U21 (IPR020177)

Short name: Herpes_glycoprotein_U21

Overlapping homologous superfamilies


Family relationships



Glycoprotein U21 (gU21) binds to MHC class I molecules in the endoplasmic reticulum and targets them from the Golgi directly to the lysosomes. Once in the lysosomes both proteins are degraded. In consequence, surface class I molecules are down-regulated and infected cells are masked for immune recognition by cytotoxic T lymphocytes [PMID: 14617346, PMID: 17467766].

gU21 is a single-pass type I membrane protein located in the host cell endoplasmic reticulum membrane. The ER-lumenal domain associates with class I MHC molecules and is responsible for lysosomal sorting [PMID: 14617346].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.