Family

Herpesvirus glycoprotein L, rhadinovirus-type (IPR020175)

Short name: Herpes_gL_rhadinovirus

Family relationships

None.

Description

Herpesviruses are enveloped by a lipid bilayer that contains at least a dozen glycoproteins. The virion surface glycoproteins mediate recognition of susceptible cells and promote fusion of the viral envelope with the cell membrane, leading to virus entry. No single glycoprotein associated with the virion membrane has been identified as the fusogen [PMID: 17299053].

Glycoprotein L (gL) forms a non-covalently linked heterodimer with glycoprotein H (gH). This heterodimer is essential for virus-cell and cell-cell fusion since the association of gH and gL is necessary for correct localisation of gH to the virion or cell surface. gH anchoring the heterodimer to the plasma membrane through its transmembrane domain. gL lacks a transmembrane domain and is secreted from cells when expressed in the absence of gH [PMID: 7769724].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
Pfam