Transcriptional repressor KorC (IPR020136)

Short name: Tscrpt_rep_KorC

Overlapping homologous superfamilies


Family relationships



KorC is a transcriptional repressor encoded on the plasmid IncP-alpha RK2 and related IncP plasmids. It acts with KorA as co-repressor in the control of expression of the kilC and kilE operons.

The kor regulon of the IncP alpha plasmid RK2 constitutes eight co-ordinately regulated operons. Over-expression of KorC reduces expression of the KorC-regulated kilC and kilE operons and severely affects the maintenance of both the IncP alpha plasmid RK2lac and the IncP beta plasmid R751 in Pseudomonas aeruginosa but has little effect on plasmid maintenance in Escherichia coli. This suggests that the kil determinant is involved in IncP plasmid maintenance [PMID: 9079921].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.