Decidual protein, progesterone induced (IPR020133)

Short name: DEPP

Family relationships



This entry represents proteins from various mammals known as DEPP proteins, which are decidual proteins induced by progesterone.

Decidualization of the endometrial stromal cells (ESC) is thought to be stimulated by progesterone and/or cAMP and is crucial for embryo implantation and placentation. Increased expression of Depp was observed in endometria during mid- and late-secretory phases and 1st trimester deciduas. Depp increased the level of phosphorylated Erk and activated the Elk-1 transcription factor in human embryonal kidney 293 cells, suggesting that Depp modulates the effects of progesterone during decidualization and in the decidua by affecting gene expression [PMID: 16123073].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.