Cortexin (IPR020066)

Short name: Cortexin

Overlapping homologous superfamilies


Family relationships



Cortexin is a neuron-specific, 82-residue membrane protein which is found especially in vertebrate brain cortex tissue. It may mediate extracellular or intracellular signalling of cortical neurons during forebrain development. Cortexin is present at significant levels in the foetal brain, suggesting that it may be important to neurons of both the developing and adult cerebral cortex. Cortexin has a conserved single membrane-spanning region in the middle of each sequence [PMID: 8336151]. In humans, there is selective expression of Cortexin 3 (CTXN3) in the kidney as well as the brain [PMID: 17786280]. This entry contains Cortexins 1, 2 and 3, and Cortexin domain-containing proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031224 intrinsic component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.