Conserved Site

Nuclear transition protein 1, conserved site (IPR020062)

Short name: Nuclear_transition_prot1_CS


Nuclear transition protein 1 (TP1) is one of the spermatid-specific proteins [PMID: 2040274]. TP1 is a basic protein well conserved in mammalian species. In mammals, the second stage of spermatogenesis is characterised by the conversion of nucleosomal chromatin to the compact, non-nucleosomal and transcriptionally inactive form found in the sperm nucleus. This condensation is associated with a double-protein transition. The first transition corresponds to the replacement of histones by several spermatid-specific proteins (also called transition proteins) which are themselves replaced by protamines during the second transition.

This entry represents a heptapeptide located in positions 28 to 34, which contains five basic residues (Arg or Lys) as well as a tyrosine that could be essential for the destabilisation of chromatin by intercalating between the bases of DNA.

GO terms

Biological Process

GO:0007283 spermatogenesis

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0000786 nucleosome
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns