DNA polymerase I-like, H3TH domain (IPR020045)

Short name: DNA_polI_H3TH

Overlapping homologous superfamilies

Domain relationships



This entry represents the H3TH (helix-3-turn-helix) domain of the 5'-3' exonuclease (53EXO) of mutli-domain DNA polymerase I and single domain protein homologues. Taq (Thermus aquaticus) DNA polymerase I contains a polymerase domain for synthesizing a new DNA strand and a 53EXO domain for cleaving RNA primers or damaged DNA strands [PMID: 9264032, PMID: 8717047]. Taq's 53EXO recognizes and endonucleolytically cleaves a structure-specific DNA substrate that has a bifurcated downstream duplex and an upstream template-primer duplex that overlaps the downstream duplex by 1 bp [PMID: 15247286].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.