Family

Proteasome alpha subunit, archaeal (IPR019982)

Short name: Proteasome_asu_arc

Overlapping homologous superfamilies

Family relationships

Description

The proteasome (or macropain) (EC:3.4.25.1) [PMID: 7682410, PMID: 2643381, PMID: 1317508, PMID: 7697118, PMID: 8882582] is a multicatalytic proteinase complex in eukaryotes and archaea, and in some bacteria, that is involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway. In eukaryotes the 20S proteasome is composed of 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700 kDa. Proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). The proteasome consists of four stacked rings composed of alpha/beta/beta/alpha subunits. There are seven different alpha subunits and seven different beta subunits [PMID: 9087403]. Three of the seven beta subunits are peptidases, each with a different specificity. Subunit beta1c (MEROPS identifier T01.010) has a preference for cleaving glutaminyl bonds ("peptidyl-glutamyl-like" or "caspase-like"), subunit beta2c (MEROPS identifier T01.011) has a preference for cleaving arginyl and lysyl bonds ("trypsin-like"), and subunit beta5c (MEROPS identifier T01.012) cleaves after hydrophobic amino acids ("chymotrypsin-like") [PMID: 2535672]. The proteasome subunits are related to N-terminal nucleophile hydrolases, and the catalytic subunits have an N-terminal threonine nucleophile.

This entry represents the alpha subunit of the archaeal proteasome (MEROPS identifier T01.970). This protein has so far been found in all completely sequenced archaeal genomes and is occasionally duplicated. The two different alpha subunits of Haloferax volcanii may have distinct physiological roles [PMID: 10482525].

GO terms

Biological Process

GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
CDD
  • cd03756 (proteasome_alpha_archeal)
HAMAP