M protein-type anchor domain (IPR019950)

Short name: M_anchor

Overlapping homologous superfamilies


Domain relationships


Viruses, parasites and bacteria are covered in protein and sugar molecules that help them gain entry into a host by counteracting the host's defences. One such molecule is the M protein produced by certain streptococcal bacteria [PMID: 26866233]. M proteins embody an anchor motif that is now known to be shared by many Gram-positive bacterial surface proteins. The motif includes a conserved hexapeptide, with the consensus sequence LPXTGE, which precedes a hydrophobic region, which itself precedes a cluster of basic residues [PMID: 2188957, PMID: 2287281].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.