Domain

Gram-positive anchor (IPR019948)

Short name: Gram-positive_anchor

Domain relationships

Description

Viruses, parasites and bacteria are covered in protein and sugar molecules that help them gain entry into a host by counteracting the host's defences. One such molecule is the M protein produced by certain streptococcal bacteria. M proteins embody a motif that is now known to be shared by many Gram-positive bacterial surface proteins. The motif includes a conserved hexapeptide, which precedes a hydrophobic C-terminal membrane anchor, which itself precedes a cluster of basic residues [PMID: 2188957, PMID: 2287281]. This structure is represented in the following schematic representation:

  +--------------------------------------------+-+--------+-+
  |    Variable length extracellular domain    |H| Anchor |B|
  +--------------------------------------------+-+--------+-+

  'H': conserved hexapeptide.
  'B': cluster of basic residues.

It has been proposed that this hexapeptide sequence is responsible for a post- translational modification necessary for the proper anchoring of the proteins which bear it, to the cell wall.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam