Family

Mutatrotase, YjhT-like (IPR019936)

Short name: Mutatrotase_YjhT-like

Overlapping homologous superfamilies

Family relationships

None.

Description

Members of this protein family contain copies of the beta-propeller-forming Kelch repeat. All are full-length homologues to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homologue of this protein.

Members of this entry converts alpha-N-acetylneuranimic acid (Neu5Ac) to thebeta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac,which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageousto the bacterium to damp down host responses.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
TIGRFAMs