Conserved Site

Cold-shock conserved site (IPR019844)

Short name: Cold-shock_CS


When Escherichia coli is exposed to a temperature drop from 37 to 10 degrees centigrade, a 4-5 hour lag phase occurs, after which growth is resumed at a reduced rate [PMID: 1912512]. During the lag phase, the expression of around 13 proteins, which contain specific DNA-binding regions [PMID: 2247479], is increased 2-10 fold. These so-called 'cold shock' proteins are thought to help the cell to survive in temperatures lower than optimum growth temperature, by contrast with heat shock proteins, which help the cell to survive in temperatures greater than the optimum, possibly by condensation of the chromosome and organisation of the prokaryotic nucleoid [PMID: 1912512]. A conserved domain of about 70 amino acids has been found in prokaryotic and eukaryotic DNA-binding proteins [PMID: 1622933, PMID: 2184368, PMID: 8022259]. This domain is known as the 'cold-shock domain' (CSD), part of which is highly similar [PMID: 1614871] to the RNP-1 RNA-binding motif.

This conserved region is located at the N-terminal. The beginning of this region is highly similar to the RNP-1 RNA-binding motif [PMID: 1614871].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns