Conserved Site

Osteopontin, conserved site (IPR019841)

Short name: Osteopontin_CS

Description

The major event of endochondrial ossification is the proteolytic degradation of calcified cartilage and the extracellular matrix, and their substitution with bone-specific extracellular matrix produced and organised by osteoblasts [PMID: 2033080]. One of the most abundant products of osteoblasts is osteopontin, a glycosylated phosphoprotein with a high acidic amino acid content and one copy of the cell attachment sequence RGD [PMID: 2033080]. It is thought that osteopontin may act as a bridge between osteoblasts and the apatite mineral of the bone [PMID: 2033080]. Osteopontin-K is a kidney protein, similar to osteopontin and probably also involved in cell adhesion [PMID: 1414488].

The signature pattern used in this entry covers a highly conserved region located at the N-terminal extremity of the mature protein.

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0001503 ossification

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns