Conserved Site

Leukemia inhibitory factor /oncostatin, conserved site (IPR019827)

Short name: Leukemia_IF/oncostatin_CS

Description

On the basis of functional and structural similarities, the small cytokines leukemia inhibitory factor (LIF) and oncostatin (OSM) can be classified into a single family [PMID: 1566332, PMID: 1717982].

It has been said [PMID: 1717982] that LIF and OSM can be included in the IL-6 family of cytokines (IPR003573), but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.

The signature pattern for this entry is based on a conserved region in the C-terminal region. This region is centred on a conserved cysteine which has been shown, in OSM, to be involved in a disulphide bond [PMID: 2026606].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0005125 cytokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns