Conserved Site

Interferon regulatory factor, conserved site (IPR019817)

Short name: Interferon_reg_fac_CS


The expression of type I interferon genes (interferons alpha and beta) is induced by many agents, including viral attack [PMID: 3409321]. Induction is mediated by the binding of interferon regulatory factor 1 (IRF-1) to a region known as the interferon consensus sequence (ICS), located upstream of the interferon genes [PMID: 1460054]. Other factors may also bind to the ICS, including IRF-2, which does not function as an activator, but rather suppresses the function of IRF-1 under certain circumstances [PMID: 2475256]. IRF proteins contain a conserved N-terminal DNA-binding region of about 120 amino acids, which folds into a structure that binds specifically to the ICS; the remaining parts of the sequences vary depending on the precise function of the protein [PMID: 1460054]. This region contains five conserved tryptophans and is known as a 'tryptophan pentad repeat'.

The signature of this entry spans the region from the second to the fourth of the five conserved tryptophans.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns