Conserved Site

Translation initiation factor 3, conserved site (IPR019813)

Short name: Translation_initiation_fac3_CS

Description

Initiation factor 3 (IF-3) (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit [PMID: 8405963]. The chloroplast initiation factor IF-3(chl) is a protein that enhances the poly(A,U,G)-dependent binding of the initiator tRNA to chloroplast ribosomal 30s subunits in which the central section is evolutionary related to the sequence of bacterial IF-3 [PMID: 8144528].

The signature pattern for this entry was made from a highly conserved region located in the central section of bacterial and plant chloroplast IF-3.

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003743 translation initiation factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns