Conserved Site

Heat-stable enterotoxin, conserved site (IPR019806)

Short name: Heat-stable_enterotox_CS


This entry represents a group of heat-stable enterotoxins, such as STa from Escherichia coli, which are an important cause of acute diarrhoea in infants and travellers in developing countries. The mature STa protein is a 19-residue peptide containing three disulphide bridges that are functionally important. STa contains an N-terminal signal peptide composed of two domains, Pre and Pro, involved in extracellular toxin release, and a core enterotoxigenic domain [PMID: 15049831]. STa binds to and activates the guanylate cyclase C intestinal receptor, causing an increase in the intracellular levels of cyclic guanosine monophosphate (cGMP) [PMID: 10799798, PMID: 17094787, PMID: 12813912].

The signature pattern used in this entry contains the 6 cysteines that are involved in disulphide bridges and the three conserved residues of the mature enterotoxin.

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns