Conserved Site

Glutamate 5-kinase, conserved site (IPR019797)

Short name: Glutamate_5-kinase_CS


Glutamate 5-kinase (EC: (gamma-glutamyl kinase) (GK) is the enzyme that catalyzes the first step in the biosynthesis of proline from glutamate, the ATP-dependent phosphorylation of L-glutamate into L-glutamate 5-phosphate.

In eubacteria (gene proB) and yeast [PMID: 1350780] (gene PRO1), GK is a monofunctional protein, while in plants and mammals, it is a bifunctional enzyme (P5CS) [PMID: 1384052] that consists of two domains: a N-terminal GK domain and a C-terminal gamma- glutamyl phosphate reductase domain (EC:

This entry represents a highly conserved glycine-and alanine- rich region located in the central section of these enzymes.

GO terms

Biological Process

GO:0006561 proline biosynthetic process

Molecular Function

GO:0004349 glutamate 5-kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns