Active Site

Glucose-6-phosphate dehydrogenase, active site (IPR019796)

Short name: G6P_DH_AS


Glucose-6-phosphate dehydrogenase (G6PD) [PMID: 8444164] catalyses the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme [PMID: 3126064]. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and is used as the pattern to identify the proteins associated with this entry.

GO terms

Biological Process

GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004345 glucose-6-phosphate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns