Conserved Site

F-actin capping protein, beta subunit, conserved site (IPR019771)

Short name: F-actin_capping_bsu_CS


The actin filament system, a prominent part of the cytoskeleton in eukaryotic cells, is both a static structure and a dynamic network that can undergo rearrangements: it is thought to be involved in processes such as cell movement and phagocytosis [PMID: 2341404], as well as muscle contraction.

The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin (see IPR007122) and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins [PMID: 2341404].

The beta-subunit is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [PMID: 2179733]. The signature pattern in this entry is a conserved hexapeptide in the N-terminal region of the beta-subunit.

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0003779 actin binding

Cellular Component

GO:0008290 F-actin capping protein complex
GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns