Conserved Site

Eukaryotic translation initiation factor 4E (eIF-4E), conserved site (IPR019770)

Short name: TIF_eIF_4E_CS

Description

Eukaryotic translation initiation factor 4E (eIF-4E) [PMID: 1733496] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures.

eIF-4E is a conserved protein of about 25 kDa. Site directed mutagenesis experiments have shown [PMID: 1672854] that a tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding. The signature pattern used in this entry includes this tryptophan.

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns