Conserved Site

Dynein light chain, type 1/2, conserved site (IPR019763)

Short name: Dynein_light_1/2_CS

Description

Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Dynein is composed of a number of ATP-binding large subunits (see IPR004273), intermediate size subunits and small subunits. Among the small subunits, there is a family of highly conserved proteins which make up this family [PMID: 7744782, PMID: 8628263].

Both type 1 (DLC1) and 2 (DLC2) dynein light chains have a similar two-layer alpha-beta core structure consisting of beta-alpha(2)-beta-X-beta(2) [PMID: 10426949, PMID: 14561217].

GO terms

Biological Process

GO:0007017 microtubule-based process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005875 microtubule associated complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns