Conserved Site

Involucrin, conserved site (IPR019743)

Short name: Involucrin_CS


Involucrin [PMID: 1359382, PMID: 8277848] is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane [PMID: 8098344] functioning as a glutamyl donor during assembly of the cornified envelope.

Structurally involucrin consists of a conserved region of about 75 amino acid residues followed by two extremely variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The total size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).

This entry represents the signature pattern for involucrin, which is located at the N-terminal extremity of these proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns