Conserved Site

Galactokinase, conserved site (IPR019741)

Short name: Galactokinase_CS

Description

Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [PMID: 3062381, PMID: 1438294]. Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly responsible for presenile cataracts in adults [PMID: 1438294]. In yeast, the GAL3 gene product is required for the GAL4-mediated induction of other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforces this process, increasing the expression of other galactose-inducible genes. GAL3 has been shown to be similar to the GAL1 protein [PMID: 3062381].

This entry represents a conserved signature pattern located in the N-terminal domain of galactokinases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns