Conserved Site

Pyridoxamine 5'-phosphate oxidase, conserved site (IPR019740)

Short name: Pyridox_Oxase_CS

Description

Pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5) is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. The sequences of the enzyme from bacterial (genes pdxH or fprA) [PMID: 1356963] and fungal (gene PDX3) [PMID: 7896706] sources show that this protein has been highly conserved throughout evolution. PdxH is evolutionary related [PMID: 8586283] to one of the enzymes in the phenazine biosynthesis protein pathway, phzD (also known as phzG).

This entry represents a highly conserved region located in the C-terminal part of these enzymes.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns