Conserved Site

Myelin P0 protein, conserved site (IPR019738)

Short name: Myelin_P0_CS

Description

The P0 protein is a major structural glycoprotein of the peripheral nervous system (PNS) myelin, which probably plays an important role for the formation and the maintenance of myelin structure; it is well conserved across species [PMID: 1285424, PMID: 1710279]. P0 is a protein of about 28 Kd that consists of three domains: a N-terminal extracellular domain of about 125 residues which seems to form a V-type immunoglobulin domain; a transmembrane region, and a cytoplasmic C-terminal domain of about 70 residues which contains many positively charged residues and which is a substrate of some serine protein kinases.

This entry represents a signature pattern located in the C-terminal part of the cytoplasmic domain that contains many positive charges and serine residues that could be phosphorylated.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns