Domain

Iron sulphur domain-containing, mitoNEET, N-terminal (IPR019610)

Short name: FeS-contain_mitoNEET_N

Domain relationships

None.

Description

The CDGSH iron sulphur domain are a group of iron-sulphur (Fe-S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].

The CDGSH iron sulphur domain protein (also referred to as mitoNEET) is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria [PMID: 17766440]. Iron in turn is essential for the function of several mitochondrial enzymes.

This entry represents the N-terminal of the mitoNEET and Miner-type proteins that carry a CDGSH-type cluster-binding domain (IPR018967) that coordinate a redox-active 2Fe-2S cluster.

In the outer mitochondrian membrane (OMM), the CDGSH 2Fe-2S-containing domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by the N-terminal domain found in higher vertebrates [PMID: 17584744, PMID: 17766440, PMID: 17376863]. The whole protein regulates oxidative capacity and may function in electron transfer, for instance in redox reactions with metabolic intermediates, cofactors and/or proteins localized at the OMM.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051537 2 iron, 2 sulfur cluster binding

Cellular Component

GO:0043231 intracellular membrane-bounded organelle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam