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Overview
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Pathways & interactions
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Cross-references
Disks large homologue 1, N-terminal PEST domain (IPR019590)
Short name: DLG1_PEST_dom
Overlapping homologous superfamilies
None.
Domain relationships
None.
Description
This domain can be found in Disks large homologue 1 (DLG1 or SAP97), a membrane-associated guanylate kinase protein (MAGUK) that serves as an important determinant of localization and organisation of ion channels into specific plasma membrane domains [PMID: 18245566].
The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination [PMID: 8755249]. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerisation of the whole protein [PMID: 18215622].