Disks large homologue 1, N-terminal PEST domain (IPR019590)

Short name: DLG1_PEST_dom

Overlapping homologous superfamilies


Domain relationships



This domain can be found in Disks large homologue 1 (DLG1 or SAP97), a membrane-associated guanylate kinase protein (MAGUK) that serves as an important determinant of localization and organisation of ion channels into specific plasma membrane domains [PMID: 18245566].

The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination [PMID: 8755249]. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerisation of the whole protein [PMID: 18215622].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.