Domain

Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding (IPR019580)

Short name: Prp8_U6-snRNA-bd

Domain relationships

None.

Description

This entry represents the interacting site for U6-snRNA, which is part of U4/U6.

U5 tri-snRNPs complex of the spliceosome is a prime candidate for the role of cofactor in the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [PMID: 16431982].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0017070 U6 snRNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam